Selective calcium sensitivity in immature glioma cancer stem cells. These disulfide bonds are essential for proper protein conformation and receptor binding. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. Delineating the importance of serum opsonins and the bacterial capsule in affecting the uptake and killing of Burkholderia pseudomallei by murine neutrophils and macrophages. The data collected includes not only links to publications in PubMed, Mature mouse IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. 5. Notch transactivates Rheb to maintain the multipotency of TSC-null cells. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). The product is shipped at ambient temperature. Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell-like side population cells. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally. For recombinant human EGF, stability and activity testing has been performed after reconstitution to 500 μg/mL. and D.V. MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer. Wij willen hier een beschrijving geven, maar de site die u nu bekijkt staat dit niet toe. Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells. Kickass - KAT - Kickasstorrents - Site Status and Official Mirrors List Neuronal differentiation and extensive migration of human neural precursor cells following co-culture with rat auditory brainstem slices. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. We only index and link to content provided by other sites. Aloha Tube - sex videos updated every 5 minutes. Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity. Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice. Pellets can be dislodged during shipping and become disbursed on the vial wall and in the cap. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. P38/NF-kappaB/snail pathway is involved in caffeic acid-induced inhibition of cancer stem cells-like properties and migratory capacity in malignant human keratinocyte. Although the vials are bottled using aseptic techniques, heat-treated vials, and sterile stock solutions, they are not considered or guaranteed to be sterile. Bio-Techne WHERE SCIENCE INTERSECTS INNOVATIONTM. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. Improved repair of dermal wounds in mice lacking microRNA-155. Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K+ channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. Suzuki, Takakuni (2019) Quantifying the Relations among Neurophysiological Responses, Dimensional Psychopathology, and Personality Traits . Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-beta-mediated migration of human lung and breast epithelial cells. Bio-Techne Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation. Activated Brain Endothelial Cells Cross-Present Malaria Antigen. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. : Their changes by serine residue mutations, Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways, High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance, NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells, Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies, Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model, SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function, Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies, Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor, SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition, Targeted BiTE expression by an oncolytic vector augments therapeutic efficacy against solid tumors, Preserving Basement Membranes during Detachment of Cultivated Oral Mucosal Epithelial Cell Sheets for the Treatment of Total Bilateral Limbal Stem Cell Deficiency, Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer, Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis, PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation, Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity, Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood, Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma, Ythdf2-mediated m6A mRNA clearance modulates neural development in mice, TGF? RGD-peptides for tissue engineering of articular cartilage. Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants. Upon receipt, store it immediately at the temperature recommended below. Human EGF protein (236-EG) is manufactured by R&D Systems, over 97% purity. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. Ezrin expression and cell survival regulation in colorectal cancer. EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. Are R&D Systems recombinant proteins and antibodies sterile? Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Muhl, H. and J. Pfeilschifter (2003) Int. Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury. Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. activity and enhances ?-catenin signaling and cell proliferation in prostate cancer cells, M�ller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture, Coding and noncoding landscape of extracellular RNA released by human glioma stem cells, Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma, Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing, Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli, Targeting the Wnt pathway and cancer stem cells with anti-progastrin humanized antibodies: a major breakthrough for K-RAS mutated colorectal cancer treatment. Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. What is the recommended method for reconstitution of a lyophilized protein or antibody? IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3beta. Reconstitute the vial as directed. CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision. An antioxidant role for catecholate siderophores in Salmonella. Mitochondrial control by DRP1 in brain tumor initiating cells. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma, Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer, Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1? BibleThe Bible is a collection of religious texts or scriptures sacred to Christians, Jews, Samaritans, Rastafari and others. Three-dimensional lung tumor microenvironment modulates therapeutic compound responsiveness in vitro--implication for drug development. Citations for Recombinant Mouse IFN-gamma Protein, IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types, IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types, Custom Services for Cell & Gene Therapies, Good Manufacturing Practice (GMP) Antibody Services, Cytokines and Receptors in Allergy and Asthma, Cytokines and Receptors in Tfh Cell Differentiation and Function, Isolation, Culture, and Identification of Natural Killer Cells, Multiple Sclerosis and Myelin Related Molecules, Search Cytokine and Growth Factor Products, Ciliary proteins specify the cell inflammatory response by tuning NF&kappaB signalling, independently of primary cilia, Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells, Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells, Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells, Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway, Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress, N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation, Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation, Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis, 2,3,4',5-Tetrahydroxystilbene-2-O-&beta-D-Glucoside (THSG) Activates the Nrf2 Antioxidant Pathway and Attenuates Oxidative Stress-Induced Cell Death in Mouse Cochlear UB/OC-2 Cells, Otoprotective Effect of 2,3,4',5-Tetrahydroxystilbene-2-O-&beta-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells, Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages, Paracrine regulation and improvement of &beta-cell function by thioredoxin, MUC16 suppresses human and murine innate immune responses, SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm, The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice, Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture, Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist, Vitamin D improves sunburns by increasing autophagy in M2 macrophages, Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy, Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells, Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis, Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation, Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation, Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe, Natural killer cells impede the engraftment of cardiomyocytes derived from induced pluripotent stem cells in syngeneic mouse model, Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1, Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1, Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein, Signal regulatory protein ? The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3). Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus, The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation, Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells, Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells, Dietary fiber sources and non-starch polysaccharide-degrading enzymes modify mucin expression and the immune profile of the swine ileum, Phosphorylation and inhibition of ceramide kinase by protein kinase C-? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis, Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects, Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis, Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy, Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections, Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, NADPH oxidases are essential for macrophage differentiation, Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status, Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. The product is shipped at ambient temperature. IFN-gamma dimers bind to IFN‑ gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Mechanisms Underlying Interferon-?-Induced Priming of Microglial Reactive Oxygen Species Production, Macrophages form functional vascular mimicry channels in vivo. Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8. Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R. O’Keefe, Susan L. Mooberry, and ; Robert H. Cichewicz* Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. Endothelial cell-derived chemerin promotes dendritic cell transmigration. Control of intracellular Francisella tularensis by different cell types and the role of nitric oxide. Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Vogel, S.N. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line. Citations: Showing 1 - 10 Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2? Mouse IFN-gamma protein (485-MI) is manufactured by R&D Systems, over 97% purity. Evidence in accelerated murine models of type 1 diabetes. Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice. and D.P. Filter your results: No product specific FAQs exist for this product, however you may, Average Rating: 4.5 IFN-gamma Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties, Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma, Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis, Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats, Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling, Targeting endogenous proteins for degradation through the affinity-directed protein missile system, Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells, Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells, Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells, Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy, Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity, LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells, Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models, Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3, Tweety-homologue 1 drives brain colonization of gliomas, TRPM4 regulates Akt/GSK3-? © Copyright 2021 R&D Systems, Inc. All Rights Reserved. TGF-beta promotes immune responses in the presence of mesenchymal stem cells. and Repression of NF-?B, TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles, Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade, A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages, The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells, Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation, Microglia activation is essential for BMP7-mediated retinal reactive gliosis, The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression. 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Medium: RPMI + 2% B-27 supplement + 1% L-glutamine + 1% Pen/Strep. signaling, Duration of simulated microgravity affects the differentiation of mesenchymal stem cells, Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array, Interleukin?6 induces an epithelial?mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration, Retention of Human-Induced Pluripotent Stem Cells (hiPS) With Injectable HA Hydrogels for Vocal Fold Engineering, Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models, Transcription factor-mediated regulation of kidney versus liver specification of Slc and Abc drug transporters, tight junction molecules and signature biomarkers, Growth hormone is permissive for neoplastic colon growth, Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production, The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling, Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion, A Highly Diverse and Functional Na�ve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents, Brain tissue banking for stem cells for our future, The FDA-approved drug sofosbuvir inhibits Zika virus infection, Glucocorticoids Suppress Mitochondrial Oxidant Production via Upregulation of Uncoupling Protein 2 in Hyperglycemic Endothelial Cells, A new NFIA:RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma, Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells, Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries, Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in Xeno/Serum-Free Condition: In Vitro and In Vivo Assessment, Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination, Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population, Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma, Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery, LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer, Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking, SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor, The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages, c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas, Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu, A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo, Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition, ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Citations for Recombinant Human EGF Protein, CF, Custom Services for Cell & Gene Therapies, Good Manufacturing Practice (GMP) Antibody Services, Search Cytokine and Growth Factor Products, Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential, Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells, LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development, Enhancing Antitumor Efficacy of Heavily Vascularized Tumors by RAMBO Virus through Decreased Tumor Endothelial Cell Activation, X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics, Generation of intestinal organoids derived from human pluripotent stem cells for drug testing, Tissue Responses to Shiga Toxin in Human Intestinal Organoids, Spatial�organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers, Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy, Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition, Control of protein function through oxidation and reduction of persulfidated states, Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer, Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells, Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells, Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy, Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies, Generation of human oogonia from induced pluripotent stem cells in culture, SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner, Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia, DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes, Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals, Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation, Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice, Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis, Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli, Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines, Astrocytes influence medulloblastoma phenotypes and CD133 surface expression, In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines, Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells, Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord Injury, Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells, Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells, Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine, Organoid culture media formulated with growth factors of defined cellular activity, Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies, Development of a Cx46 Targeting Strategy for Cancer Stem Cells, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration, ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD, Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis, A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma, Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations, Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue, MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration, Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation, Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy, c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells, Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation, A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS), Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR, Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms, High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures, Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness, Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration, CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors, Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma, PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133, Modeling Patient-Derived Glioblastoma with Cerebral Organoids, RUNX represses Pmp22 to drive neurofibromagenesis, CIC protein instability contributes to tumorigenesis in glioblastoma, Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model, Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells, Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma, Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: development of 3D primed therapeutic MSCs, Excess growth hormone suppresses DNA damage repair in epithelial cells, Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale, Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line, Autonomous trisomic rescue of Down syndrome cells, Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma, Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ, Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration, Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma, Generation of human antral and fundic gastric organoids from pluripotent stem cells, Evaluating S. flexneri pathogenesis in the human enteroid model, Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures, Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders, Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation, Isolation and characterization of myogenic precursor cells from human cremaster muscle, Reliability of human cortical organoid generation, MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway, Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death, AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation, Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis, Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids, Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome, Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth, Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation, SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis, Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer, miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer, Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion, Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers, Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking, Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals, Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression, MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation, Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells, Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner, Efficient One-Step Induction of Human Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Produces MSC-Derived Neurospheres (MSC-NS) with Unique Transcriptional Profile and Enhanced Neurogenic and Angiogenic Secretomes, The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo, Neurospheres induced from human adipose-derived stem cells as a new source of neural progenitor cells, CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus, Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering, Cardiac Magnetic Resonance Imaging used for Evaluation of Adipose-Derived Stromal Cell Therapy in Patients with Chronic Ischemic Heart Disease, TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis, MicroRNA-548 regulates high mobility group box 1 expression in patients with preterm birth and chorioamnionitis, Identification and Classification of Hubs in microRNA Target Gene Networks in Human Neural Stem/Progenitor Cells following Japanese Encephalitis Virus Infection, The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients, Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells, Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen, Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors, Non-proliferative neurogenesis in human periodontal ligament stem cells, Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling, Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas, Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats, Isolation and characterization of mesenchymal stem cells from human fetus heart, New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status, Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors, miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP, Acoustic waves improves retroviral transduction in human retinal stem cells, Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3.
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